PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G43840.1
Common NameAT-HSFA6A, HSF19, HSFA6A, MQD19.20
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family HSF
Protein Properties Length: 282aa    MW: 33155.6 Da    PI: 5.4814
Description heat shock transcription factor A6A
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G43840.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind116.51.6e-36191121103
                   HHHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXX CS
  HSF_DNA-bind   1 aFlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkelleki 97 
                   aFl+k+y+i+ed+++++++sws+++nsf+v+++e+fa  +Lp+ Fkh+nf+SFvRQLn+YgFkk+++e+         weF++++F kg+++ll++i
   AT5G43840.1  19 AFLTKTYNIVEDSSTNNIVSWSRDNNSFIVWEPETFALICLPRCFKHNNFSSFVRQLNTYGFKKIDTER---------WEFANEHFLKGERHLLKNI 106
                   69****************************************************************999.........******************* PP

                   XXXXXX CS
  HSF_DNA-bind  98 krkkse 103
                   kr+k++
   AT5G43840.1 107 KRRKTS 112
                   ***986 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM004152.3E-5316109IPR000232Heat shock factor (HSF)-type, DNA-binding
SuperFamilySSF467851.77E-3416109IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.0E-3617109IPR011991Winged helix-turn-helix DNA-binding domain
PRINTSPR000561.4E-172043IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004479.2E-3120109IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.4E-175870IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS0043405983IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.4E-177183IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0009025anatomyvascular leaf
PO:0007115developmental stageLP.04 four leaves visible stage
Sequence ? help Back to Top
Protein Sequence    Length: 282 aa     Download sequence    Send to blast
MDYNLPIPLE GLKETPPTAF LTKTYNIVED SSTNNIVSWS RDNNSFIVWE PETFALICLP  60
RCFKHNNFSS FVRQLNTYGF KKIDTERWEF ANEHFLKGER HLLKNIKRRK TSSQTQTQSL  120
EGEIHELRRD RMALEVELVR LRRKQESVKT YLHLMEEKLK VTEVKQEMMM NFLLKKIKKP  180
SFLQSLRKRN LQGIKNREQK QEVISSHGVE DNGKFVKAEP EEYGDDIDDQ CGGVFDYGDE  240
LHIASMEHQG QGEDEIEMDS EGIWKGFVLS EEEMCDLVEH FI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2ldu_A5e-22911211123Heat shock factor protein 1
5d5u_B6e-22411113131Heat shock factor protein 1
5d5v_B6e-22411113131Heat shock factor protein 1
5d5v_D6e-22411113131Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1102108LKNIKRR
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO184223770.0
Genevisible249117_at0.0
Expression AtlasAT5G43840-
AtGenExpressAT5G43840-
ATTED-IIAT5G43840-
Functional Description ? help Back to Top
Source Description
TAIRmember of Heat Stress Transcription Factor (Hsf) family
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Function -- GeneRIF ? help Back to Top
  1. AtHsfA6a acts as a transcriptional activator of stress-responsive genes via the abscissic acid-dependent signalling pathway.
    [PMID: 24313737]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00541DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G43840.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G28520
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G43840
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankDQ4470350.0DQ447035.1 Arabidopsis thaliana clone pENTR221-At5g43840 heat shock transcription factor family protein (At5g43840) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_199197.10.0heat stress transcription factor A-6a
SwissprotQ1PDN30.0HFA6A_ARATH; Heat stress transcription factor A-6a
TrEMBLD7MNK40.0D7MNK4_ARALL; AT-HSFA6A
STRINGAT5G43840.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM156831416
Representative plantOGRP9617233
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Nover L, et al.
    Arabidopsis and the heat stress transcription factor world: how many heat stress transcription factors do we need?
    Cell Stress Chaperones, 2001. 6(3): p. 177-89
    [PMID:11599559]
  3. Jiao Y, et al.
    A genome-wide analysis of blue-light regulation of Arabidopsis transcription factor gene expression during seedling development.
    Plant Physiol., 2003. 133(4): p. 1480-93
    [PMID:14605227]
  4. Underwood BA,Vanderhaeghen R,Whitford R,Town CD,Hilson P
    Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.
    Plant Biotechnol. J., 2006. 4(3): p. 317-24
    [PMID:17147637]
  5. Osuna D, et al.
    Temporal responses of transcripts, enzyme activities and metabolites after adding sucrose to carbon-deprived Arabidopsis seedlings.
    Plant J., 2007. 49(3): p. 463-91
    [PMID:17217462]
  6. Xin Z,Mandaokar A,Chen J,Last RL,Browse J
    Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.
    Plant J., 2007. 49(5): p. 786-99
    [PMID:17316173]
  7. Zhang X,Wollenweber B,Jiang D,Liu F,Zhao J
    Water deficits and heat shock effects on photosynthesis of a transgenic Arabidopsis thaliana constitutively expressing ABP9, a bZIP transcription factor.
    J. Exp. Bot., 2008. 59(4): p. 839-48
    [PMID:18272919]
  8. Guo J, et al.
    Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis.
    J Genet Genomics, 2008. 35(2): p. 105-18
    [PMID:18407058]
  9. Wohlbach DJ,Quirino BF,Sussman MR
    Analysis of the Arabidopsis histidine kinase ATHK1 reveals a connection between vegetative osmotic stress sensing and seed maturation.
    Plant Cell, 2008. 20(4): p. 1101-17
    [PMID:18441212]
  10. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  11. Hwang SM, et al.
    Functional characterization of Arabidopsis HsfA6a as a heat-shock transcription factor under high salinity and dehydration conditions.
    Plant Cell Environ., 2014. 37(5): p. 1202-22
    [PMID:24313737]